Chemoenzymatic synthesis of enantiopure hydroxy sulfoxides derived from substituted arenes.
نویسندگان
چکیده
Enantiopure β-hydroxy sulfoxides and catechol sulfoxides were obtained, by chemoenzymatic synthesis, involving dioxygenase-catalysed benzylic hydroxylation or arene cis-dihydroxylation and cis-diol dehydrogenase-catalysed dehydrogenation. Absolute configurations of chiral hydroxy sulfoxides were determined by X-ray crystallography, ECD spectroscopy and stereochemical correlation. The application of a new range of β-hydroxy sulfoxides as chiral ligands was examined.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 9 شماره
صفحات -
تاریخ انتشار 2016